As you may or may not know, my day job is to be a scientist. I work at a small pharmaceutical company in their skin biology or “IVPT” (In Vitro Permeation Testing) department. Let me warn you right now, if you’re squeamish about dead stuff/the human body you should probably click away. I’ve got nice, fun articles about traveling in New York or making yummy veggie squares that are not gross at all.
Okay, non-squeamish people, thank you for sticking with me! My job is to test various topical products (skin ointments, creams, gels, etc) on various membranes, most commonly on human cadaver skin. I’ve also worked with fresh/flash frozen human skin (skin that was removed during surgery), pig skin, and nasal tissue cultures.
My least favorite was the pig skin; after awhile I couldn’t get those little dead piggies out of my head. I don’t know how folks work with animals that they are conducting studies on and then have to euthanize. It’s definitely not for me! However, it is a necessary evil: the FDA requires animal testing for all pharmaceuticals (including things like sunscreen) before they can reach human clinical trials. Luckily, there is no live animal testing at my company, and the pig skin (which was harvested off-site) is my only experience working on any kind of animal testing.
Most of my work is with human cadaver skin, which is donated by 100% consenting human adults! I am tasked with mounting pieces of skin onto diffusion cells, applying a topical formulation on top, and removing samples throughout the testing period. I also have to separate the skin layers and process the samples for analysis. They’re then passed on to another scientist who analyzes the samples on a Liquid Chromatography/Mass Spectrometry or High Performance Liquid Chromatography/fluorescence detector. Analysis is super complex and not my job so I’m not even going to try to explain it!
I’ve also done a variety of non-lab work for the support of the skin biology department. Writing protocols, placing skin orders (way creepier sounding than it is. I like to say “My job is to order dead people’s skin off the internet.”), organizing tissues and other supplies, and other boring office stuff are the less-cool parts of my job.
I mostly wanted to share with you all a little bit more about me. I hope you learned something new! The US’s drug approval process is long (10-15 years) and I participate in one tiny sliver of it. There are definitely movements to shorten the process, but having seen a little of the behind-the-scenes, let me tell you, you do not want it shortened at the expense of your safety. So much goes into testing the safety, stability, and bioavailability* that it’s difficult and unsafe to rush.
I would love to see a reduction in animal testing, which brings me to my secondary goal with this post: to encourage you to become an organ donor/donate your body to science. So many fields benefit from having real human organs/bodies to conduct tests on; from pharmaceuticals to medical schools, to forensic science to transplant centers: the list goes on and on. An increase in the availability of human organs in pharmaceuticals would not only reduce the animal testing needed, but increase the accuracy and reliability of the results. I’ve linked a few different guides to the steps you need to take to donate your body to science.
Are you an organ donor? Do you plan to donate your body to science? Why or why not? Tell me about it in the comments below! Share this post via Facebook or Twitter and, as always, follow me here on WordPress for more GREAT content like this!
*basically how well the drug will actually work with your body. See linked article for a more detailed explanation.